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Conjugation reactions usually involve metabolite activation by a highenergy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product (Hodgson, 2004)

Sci ., 218 , 209212

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Rodent ALDH1A1 possesses a very low Km (15 M) for acetaldehyde oxidation 34 , underscoring its significant contribution to acetaldehyde metabolism in this species